Welcome to the Lee BioNMR Research Lab Page!
The focus of our group is to investigate connections between the function, structure, and dynamics of biomolecules using Nuclear Magnetic Resonance (NMR) spectroscopy.
We're at the CTR Building, HSC Campus, University of Louisville, KY!
Most Recent Featured Publication
In a collaboration with the Blackburn lab (University of Kentucky), we screened a panel of FDA-approved drugs to find an inhibitor of PRL3, an oncogenic phosphatase. We combined biochemical and cellular assays and molecular modeling to describe possible mechanism of two PRL3-specific inhibitors. Read about this in our recent pre-print.
Featured On-Campus Collaborations at the University of Louisville
Bioengineering: The Lee group assisted the laboratory of Dr. Jill Steinbach-Rankins of the Department of Bioengineering in characterizing their electrospun fibers formulated as a delivery system. Our paper, "pH-Responsive Delivery of Griffithsin from Electrospun Fibers," has now been accepted for publication in the European Journal of Pharmaceutics and Biopharmaceutics. We are always open for collaborations in a wide range of fields where NMR spectroscopy can be applied. Do not hesitate to contact us or drop by our lab!
Medicine/Brown Cancer Center: Through collaborations with multiple labs across the James Graham Brown Cancer Center, particularly the Sabo lab, we deliver the first structure of human guanylate kinase. Studies in lung cancer cell lines additionally reveal the potential of hGMPK as an important molecular target. Check out the paper here. Also check out the research of the other teams: Dr. Levi Beverly, Dr. John Trent, Dr. Manfred Konrad (MPI-BC), and Dr. Mike Sabo.