Welcome to the Lee BioNMR Research Lab Page!
The focus of our group is to investigate connections between the function, structure, and dynamics of biomolecules using Nuclear Magnetic Resonance (NMR) spectroscopy.
We're at the CTR Building, HSC Campus, University of Louisville, KY!
Most Recent Featured Publication
First ever structure (PDB:6NUI) of the human guanylate kinase, the only known enzyme responsible for cellular GDP production, is solved by our group in collaboration with, and led by the Sabo group (Medicine). We also show potential for GMPK as an important drug discovery target for lung cancer.
Recent Lab News
Graduate student, Mark, passes his qualifying exam and advances to Doctoral Candidacy! He is also selected to be part of the 2019 Cohort of the American Society for Biochemistry and Molecular Biology's Advocacy Training Program. Meanwhile, former undergraduate intern, Alicia, re-joins the lab as part of the NCI R25 Cancer Education Program.
The lab is awarded two EVPRI Internal Grants for A.Y. 2019-2020, which will allow us to explore new projects involving protein-drug interactions. Stay tuned to learn more!
Featured On-Campus Collaborations at the University of Louisville
Bioengineering: The Lee group assisted the laboratory of Dr. Jill Steinbach-Rankins of the Department of Bioengineering in characterizing their electrospun fibers formulated as a delivery system. Our paper, "pH-Responsive Delivery of Griffithsin from Electrospun Fibers," has now been accepted for publication in the European Journal of Pharmaceutics and Biopharmaceutics. We are always open for collaborations in a wide range of fields where NMR spectroscopy can be applied. Do not hesitate to contact us or drop by our lab!
Medicine/Brown Cancer Center: Through collaborations with multiple labs across the James Graham Brown Cancer Center, particularly the Sabo lab, we deliver the first structure of human guanylate kinase. Studies in lung cancer cell lines additionally reveal the potential of hGMPK as an important molecular target. Check out the paper here. Also check out the research of the other teams: Dr. Levi Beverly, Dr. John Trent, Dr. Manfred Konrad (MPI-BC), and Dr. Mike Sabo.